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A complementary survey among 300 children of the same area showed only one case of gambiense disease. The present study, conducted among 24 subjects living in villages having from zero to 40 years of contact with "tsetse" flies, has confirmed an important preponderance of antibodies. The risk of infection was inversely related to years of stay in the village and to the frequency of contact with tsetse flies. Males had a greater chance of infection than females. The risk was higher for people born before the year 1960. These preliminary results suggest that only a small proportion of Gambians have been exposed to natural infection.Differential diagnosis of inflammatory skin diseases with therapeutic trials. 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